Excess Extra Fat Loss Diet Regime Regime – How To Greatly Reduce Excess Weight Fast

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By EricHanson | July 20, 2011

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Posted in: Excess,Extra,Greatly,Reduce,Regime,Weight

Grief as we have never known it

What causes sadness when you are over 50? Harm to a child obviously, or to a spouse. Perhaps the diagnosis of an illness, or the sound of distant thunder at a summer party, as Philip Larkin called impending old age. But there is another source – and more and more of us face it.

A wave of desolation came over me the other day when I passed a shop on a slightly down-at-heel street near the centre of the city of Bath. The shop sells computer games; they are displayed on wooden shelves. The same dark wood has been used on the outside, crenellated to make it look like a stone column – the kind of stone column that the Romans built. To modern day passers-by the effect is mildly odd – we are pretending to be Roman! – but to me the wood has meaning.

Decades ago this was the headquarters of one of Bath’s best-known companies: Roman City Coaches. Once upon a time, Roman City Coaches were my whole life.

Well, Roman City Coaches and mum.

Every year, Roman City Coaches would bring out their brochure for the summer day-trips, and every year I would go into the shop with my mother to pick up the brochure from the dark wooden shelves and circle the trips we would make instead of a summer holiday. My home circumstances were odd, being the only child of a single mother, and we were hard up, but this was no meagre substitute for fun: to a solemn little boy who wanted above all else to be a coach driver, and a mother happy to sit with him to Swansea and the Mumbles or Plymouth via Dartmoor (I think that was the best: only an hour in Plymouth before the trip home), well, this was heaven.

So it saddened me in a shocking way to see the shop again and to feel what I felt: not just nostalgia but a raw pain at the loss of my mother. Although I shared it with no one at the time, I must say I also felt, mixed with the grief, more than a hint of embarrassment.

Is it acceptable, when you are fully grown up yourself, to be distraught for so long at the death of your own parents? It seems somehow self-indulgent. Fine to be sad as they say their goodbyes, to feel a pang as you clear out a family home, but, once the loss is recognised and dealt with, time to be, well, adult about it yourself.

My mother died five years ago this summer. There we are: time to be the responsible person that you want to be – the person to whom others turn for comfort.

And yet. A friend’s father died recently, and it left him cut up in a way he found similarly shocking. My friend had reached middle age, married and with children. He noticed, though, that the loss hit him even harder than the loss of his mother, who had died when he was in his mid-twenties.

The difference he put down to his own place in the journey. He had missed his mother but still been imbued then with the sense of possibility and potential that his own life represented. He might still have been a coach driver – or whatever. Years later, with his own life set in stone and not the huge success he had half-imagined when young, the death of his father seemed far more viscerally affecting. Here we go, it seemed to say to him. You’re next. Soon.

I wonder if there is a whole generation of us coping with this added psychological burden in later life, a burden born of older parents and the medical advances that keep those parents alive for much longer. As a nation, we have been debating recently how to pay for care in later life, but it seems to me that this is only one aspect of the change in our society that longevity has brought.

The other big change is late-onset grief. In what my children call the olden days (the 1960s or earlier), your parents generally popped off while you were still young and vigorous. Now they are saying their goodbyes as goodbyes, or at least retirement, starts to weigh on your own mind. I remember leaning over my mother’s deathbed and finding it quite difficult to straighten up again. Death, in these circumstances, sucks more from your life than it might have in years gone by.

“Our society isn’t very good at dealing with grief; we have a tendency to rush people,” says the clinical psychologist Dr Sylvia Dillon. “Often we allow ourselves a couple of weeks to get over losing a loved one, when in reality it can take years. Grieving a loved one when you’re older is particularly difficult, partly because we’re supposed to be grown up, and partly because when we are young, we are so busy exploring the world that we get distracted and don’t allow ourselves time to grieve.”

And my mother’s death was relatively pain-free and relatively fast. Many families are dealing with the stresses of degeneration that does not quite finish someone off, a grief that must seem endless. A cruel sense – for those left behind in their late middle age – of the grim proximity to their own fates.

Being 50 does bring its privileges, however, and one of them is the right to admit finally that you never really understood what Immanuel Kant was getting at. But one thing he said I did grasp in my student days, and it seems relevant to the condition I describe. Kant called The Enlightenment a moment when mankind became mature; we were able to think about life, the universe, everything, without seeking guidance from God. While your parents are still alive, however much you might sublimate it or ignore it or pretend it is not there; however much they might seem now to depend on you, you are still young. Or younger. Only once they go are you fully mature. And what you discover is what the human race discovered post-Enlightenment: great freedom and great sadness.

We should get help from the EU. Or some kind of big-society grant. Or maybe just recognise the fact that our generation, fiftysomethings and above, have had a pretty good deal, but face in later years a hurdle we had perhaps not expected.

After lives free of world war, educations paid for by the state, and (relatively) generously funded pensions, we face the hurdle of finally growing up, long after the idea seemed remotely attractive. Granny is dead or dying, and Dad is upset, and this is the way of the modern world.

Justin Webb is a presenter on Radio 4’s 'Today’ programme

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Posted in: Grief,known,never

Richer people less likely to care for parents

Increasing a person's wage can cause a significant drop in the amount of time they spend helping their parents with household chores, errands and transport.

For every ten per cent rise in their salary women will spend 36 per cent less time providing care and men will reduce their input by 18 per cent.

Having a sibling or other person equipped to help out makes the effect even more severe.

Olena Nizalova, of the Kiev Economics Institute, said her study on long-term care in America and Europe demonstrates that current global policies towards making care affordable are not compatible with each other.

Providing care for the elderly is becoming an ever more difficult problem because birth rates are declining and people are living longer and reaching retirement in record numbers.

Economists have suggested that the burden could be reduced by encouraging more women to take jobs and raising the retirement age in order to increase the workforce, and urging the families and friends of the elderly to provide more informal care themselves.

But the findings from the new study indicate that earning more money would be likely to lower rather than raise the amount of time people spend looking after their elderly relatives.

Involving an elderly person's wider family and friends in their care could also cause their children to more dramatically reduce the amount of time they spend helping out as their earnings rise.

The study of 2,790 American men and women who had at least one parent or parent-in-law alive in 1998 will be presented at a meeting of economics Nobel Laureates in Lindau, Germany.

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Posted in: likely,Parents,people,Richer

A New Way to Figure Your Net Worth

Here’s a statistic that really irked me from a new Merrill Lynch Wealth Management poll released last week: When asked what life lessons are most important to impart to their children, 51 percent of the 1,000 affluent adults surveyed, cited “financial know-how” while only 11 percent said “staying physically fit.”

Despite the fact that 40 percent of the same survey group said “health care costs” are keeping them up at night, they don’t seem to be getting the message that health is wealth and there’s nothing more valuable for kids to inherit than respect for themselves. After all, without a modicum of fitness, how are you ever going to live long enough to enjoy the results of your financial smarts?

Two years ago, the Environmental Protection Agency bummed everyone out by reckoning that an American life wasn’t worth as much as it used to be. The “value of a statistical life,” as it was termed, dropped by nearly $1 million from 2003 to 2008 to its current $6.9 million level. (How the EPA figured that is complicated, but it’s basically a cost-benefit analysis that helps various government agencies determine whether certain life-enhancing restrictions like more pollution controls are justified.) Although $6.9 million is still substantial enough to make me stand taller in front of the mirror and wonder what I can afford using only myself as collateral, it’s still sobering to know that –- like most financial assets these days -– the portfolio of Joe is more volatile than ever.

That’s why the time has come for a broader definition of wealth, one that encompasses more than just money and material assets, and one that will help counter market cycles with other varieties of riches. The next time you’re figuring your net worth, here are a few new things to include:

The state of your health: Whatever your age, if you’re vibrant and disease-free, double your financial net worth. If you’re fat and out-of-shape, take away half.

The love of family and friends: If you have a happy relationship, one or two trustworthy friends, kids who still call you (and ask for nothing), and especially a dog who pees with joy when you come home, double it again.

Having steady, satisfying work: The value of this portion of the portfolio went up dramatically in recent years. If you can honestly nod your head to this, you are indeed blessed, and your net worth has doubled yet again.

Still having your parents: I lost my dad 15 years ago, and I still miss him to this day. No matter how much they hassle us, they provide a reassuring safety net. And when they pass away, you become acutely aware that you’re next. Add 50 percent

These are just a few of the things I value and measure my real wealth by. Add whatever else you’d like; the list should be as individual as you are.

Who knows? When approached this way, you could be a billionaire.

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This is an absolutely beautiful post. Thank you! At EARN, where I work, we're always encouraging our "Savers" -- low-income workers who, through our nonprofit, save toward proven financial assets -- to take care of each aspect of their health (financial, physical, mental, emotional). So glad to hear that echoed from your end.

Thought you might be interested in an upcoming webinar EARN is hosting: Do Financial Assets Matter for Health? (http://bit.ly/9bdReQ) Hope you can join!

 

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Posted in: Figure,Worth

Women's drug deaths up 10%, official figures show

Opiates were the substances most commonly associated with drug deaths, with 791 people dying from heroin or morphine poisoning Photo: PA

The Office for National Statistics said the total number of deaths caused by drug poisoning – including the misuse of illegal substances - was 2,747 in 2010 – a 5% drop on the previous year.

While men made up 70% of drug-related deaths, the figures showed a 10% decrease in male fatalities from 2098 to 1890, and a corresponding 10% rise in female deaths, from 780 to 857.

Gender differences were also apparent in the underlying causes of drug poisoning deaths, with "accidental poisoning" forming the largest category of male deaths but "intentional self-poisoning and poisoning of undetermined intent" forming the highest proportion of fatalities in women.

The statistics show opiates were the substances most commonly associated with drug deaths last year with 791 people dying from heroin or morphine poisoning.

The figures showed 355 deaths involved the heroin substitute methadone, 144 involved cocaine and 56 involved amphetamines.

The ONS also said the number of deaths involving ecstasy has declined each year from 2006 to 2010. There were only eight deaths attributed to ecstasy in 2010.

It said there were six deaths involving mephedrone in 2010, the first year it had been mentioned on death certificates in England and Wales.

But the report added: "The number of deaths involving other so-called legal highs have fallen slightly in 2010, and are low relative to the number of deaths from heroin/morphine."

Health minister Anne Milton said: "These findings underline that any kind of drug abuse can harm.

"Any death related to misuse of drugs is a tragedy for the victim, their families and their friends. We want to do everything we can to drive down the harm caused by drugs.

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Posted in: deaths,figures,official,Womens

Prunes Help Prevent Fractures And Osteoporosis

Main Category: Bones / Orthopedics
Also Included In: Nutrition / Diet
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When it comes to improving bone health in postmenopausal women - and people of all ages, actually - a Florida State University researcher has found a simple, proactive solution to help prevent fractures and osteoporosis: eating dried plums.

"Over my career, I have tested numerous fruits, including figs, dates, strawberries and raisins, and none of them come anywhere close to having the effect on bone density that dried plums, or prunes, have," said Bahram H. Arjmandi, Florida State's Margaret A. Sitton Professor and chairman of the Department of Nutrition, Food and Exercise Sciences in the College of Human Sciences. "All fruits and vegetables have a positive effect on nutrition, but in terms of bone health, this particular food is exceptional."

Arjmandi and a group of researchers from Florida State and Oklahoma State University tested two groups of postmenopausal women. Over a 12-month period, the first group, consisting of 55 women, was instructed to consume 100 grams of dried plums (about 10 prunes) each day, while the second - a comparative control group of 45 women - was told to consume 100 grams of dried apples. All of the study's participants also received daily doses of calcium (500 milligrams) and vitamin D (400 international units).

The group that consumed dried plums had significantly higher bone mineral density in the ulna (one of two long bones in the forearm) and spine, in comparison with the group that ate dried apples. This, according to Arjmandi, was due in part to the ability of dried plums to suppress the rate of bone resorption, or the breakdown of bone, which tends to exceed the rate of new bone growth as people age.

The group's research, "Comparative Effects of Dried Plum and Dried Apple on Bone in Post Menopausal Women," was published in the British Journal of Nutrition. Arjmandi conducted the research with his graduate students Shirin Hooshmand, Sheau C. Chai and Raz L. Saadat of the College of Human Sciences; Dr. Kenneth Brummel-Smith, Florida State's Charlotte Edwards Maguire Professor and chairman of the Department of Geriatrics in the College of Medicine; and Oklahoma State University statistics Professor Mark E. Payton.

In the United States, about 8 million women have osteoporosis because of the sudden cessation of ovarian hormone production at the onset of menopause. What's more, about 2 million men also have osteoporosis.

"In the first five to seven postmenopausal years, women are at risk of losing bone at a rate of 3 to 5 percent per year," Arjmandi said. "However, osteoporosis is not exclusive to women and, indeed, around the age of 65, men start losing bone with the same rapidity as women."

Arjmandi encourages people who are interested in maintaining or improving their bone health to take note of the extraordinarily positive effect that dried plums have on bone density.

"Don't wait until you get a fracture or you are diagnosed with osteoporosis and have to have prescribed medicine," Arjmandi said. "Do something meaningful and practical beforehand. People could start eating two to three dried plums per day and increase gradually to perhaps six to 10 per day. Prunes can be eaten in all forms and can be included in a variety of recipes."

The U.S. Department of Agriculture funded Arjmandi's research. The California Dried Plum Board provided the dried plums for the study, as well as some funding to measure markers of oxidative stress.

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Posted in: Fractures,Osteoporosis,Prevent,Prunes

Gene Mutation Found in Uterine Fibroids

Discovery May Lead to Targeted Therapies for These Common, Benign Tumors

Aug. 25, 2011 -- Mutations in a single gene MED12 occur in about 70% of uterine fibroids, Finnish researchers find.

"This is a giant step toward understanding why fibroids arise -- but toward design of targeted therapies it is a very early step," study leader Lauri A. Aaltonen, MD, PhD, of the University of Helsinki, says in a news release. "Let's hope that this journey has begun."

Fibroids, also known as leiomyomas, are noncancerous growths of the uterus. As many as 60% of women develop fibroids by age 45.

In about half of all cases, fibroids cause problems. This may be because of their size, their location in the uterus, or the number of fibroids. Symptoms can include abnormal vaginal bleeding, painful menstruation, abdominal pain, and pain during sex. They can also lead to infertility. Fibroids are the most common reason for hysterectomy -- surgical removal of the uterus.

Previous research has linked several genetic changes to fibroids. But these occur only in a minority of cases, so Aaltonen's team searched for much more common genetic alterations.

They examined 18 fibroids collected from 17 patients. Using a technique called exome sequencing, they compared all protein-coding genes in the fibroids to those of normal tissue. Ten of those 18 fibroids displayed a mutation.

When the researchers examined an additional 207 fibroids from 80 patients, their analysis confirmed the "striking frequency" of the genetic mutations of MED12. Based on their findings, they conclude that such mutations likely play a key role in the development of fibroids.

Their findings appear in today's online issue of the journal Science.

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Posted in: Fibroids,Found,Mutation,Uterine

Home checks for high blood pressure 'will cut deaths'

Patients suspected of having high blood pressure are to be given home monitoring devices over fears millions have been misdiagnosed because they were simply nervous in the doctor's surgery.

About a quarter of people become anxious while they have their blood pressure taken in the surgery, meaning they potentially give a misleading reading. This wrongly pushes many into the high blood pressure zone, a phenomenon known as white coat hypertension. This means up to three million people could be taking drugs needlessly or in incorrect doses.

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Posted in: blood,checks,deaths,pressure

Tips In Choosing The Latest Weight Loss Supplements And Pills

« Acai Berry Select | Home | HCG Functions – Basic Principles Of The HCG Diet »

By EricHanson | July 15, 2011

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W?аt I mean wіt? t?аt іѕ t?аt everyone ?аѕ t?еіr ?w? specific body type w?іс? responds t? weight loss ?r weight gain accordingly. Bеса?ѕе ?f t?аt, іt іѕ quite difficult t? find a company t?аt са? artificially mаkе natural fаt burners. W?е? a person’s physique іѕ t?е kind t?аt burns fаt slowly, chances аrе t?еу ?а?е t? take a different sort ?f weight loss pill t?а? а? individual whose body gains muscle quickly. Otherwise, t?е individual involved іѕ going t? notice several less-t?а?-stellar results а?? become very disheartened.

Slimming down itself isn’t a quite simple task. I? fact, t?е weight loss market іѕ one ?f t?е bі??еѕt industries ?? earth – а?? bеса?ѕе people w?? аrе working within t?е weight loss sector understand t?аt losing weight іѕ a hassle f?r а?m?ѕt anyone.

A?? ѕ?, having ѕаі? t?аt, ??w са? у?? come асr?ѕѕ weight loss supplements t?аt са? аѕѕіѕt у?? t? lose weight without costing а? arm а?? a leg? T?аt’s very easy – investigate!

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Aftеr у???ve found something w?іс? seems t? ?а?е a respectable amount ?f reviews t? іt, у?? ѕ????? bе?і? t? look towards t?е value. S????? t?е cost seems t? bе a bit expensive, у?? mі??t ?іkе t? ј?ѕt mаkе note ?f іt. H?wе?еr, ?? remember t?аt у?? tend t? ?еt w?аt у?? pay f?r. A? economical weight loss supplement іѕ going t? provide inexpensive results. Likewise, a reasonably high-priced weight loss pill wі?? provide nice results.

Y?? ѕ????? ?еt enough t? w?еrе іt са? last у?? 8 weeks. I? t?іѕ way, у?? mау test out t?е pill а?? find out w?іс? kind ?f outcomes у?? с???? асq?іrе wіt? іt. If у?? са??t obtain t?е type ?f benefits у?? аrе searching f?r within 8 weeks, t?е? у??r best bet с???? t? m??е one. Yеt, іf у?? followed everything mentioned і? t?іѕ article, t?е? у???re ?іkе?у t? bе heading down t?е appropriate way а?? ?а?е absolutely nothing t? bother аb??t – у???ll bе seeing benefits.

People w?? аrе searching t?е Internet f?r info аb??t t?е topic ?f weight loss, t?е? please check out t?е link t?аt wаѕ mentioned і? t?іѕ passage.

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Posted in: Choosing,Latest,Pills,Supplements,Weight

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Posted in: Energy

How Job Loss Can Make You a Better Parent

When the economy falters and money gets tight, one of the many things we worry about is becoming less of a father or mother. Job loss only exacerbates the fears. That’s because most of us equate a good portion of parenting with providing. But a recent study published in the Journal of Political Economy found that children’s health actually improves during economic downturns.

But before digging into the details of that study, I want you to meet my neighbor, Rick. He’s in his 40s and out of work for the first time in his life. Since he has four kids and a big house, he’s pretty distressed about it. But he’s been staying busy by helping his eldest son fix up his first car and coaching the others in soccer. He even set up two big nets in his front yard.

That study I mentioned was conducted in Colombia, South America — a long way from Rick’s home in suburbia. Researchers there matched coffee prices over a 36-year period with various indicators of child health. They discovered that when the coffee market was booming, illness and mortality rates increased among kids. Conversely, when the market tanked, child health dramatically improved.

You don’t need a Ph.D. to figure out what’s happening here. In boom times, Mom and Dad are working so much that their time and attentiveness are compromised. But in tough years, the situation is reversed. Although parents may have less money, they have more of life’s most previous resource: time. And as a result, their priorities shift.

If you’re thinking that the situation in Colombia is in no way applicable to America, you’re wrong. Other studies have found the same correlation in the U.S. and other well-off nations.

So when I look out my window and see Rick helping his son change the oil in his car or dribbling a soccer ball, I think that no matter how stressful and humbling being out-of-work may be, the memories and bonds he’s creating now with his boys will make him (and them) far richer in the long run.

As we continue to muddle through whatever we’re in, try to keep that in mind if you’re an out-of-work parent. Although you may not be smiling, your kids most certainly are. In fact, they might even be healthier for it.

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Posted in: Better,Parent

Brain-Eating Amoeba FAQ

Rare, Fatal Amoeba Infection: Your Questions Answered

Aug. 18, 2011 -- Brain-eating amoebas have killed three young Americans this summer.

What is this scary bug? How does it get to the brain? Where is it, and how can you avoid it? WebMD answers these and other questions.

Amoebas are single-celled organisms. The so-called brain-eating amoeba is a species discovered in 1965 and formally named Naegleria fowleri. Although first identified in Australia, this amoeba is believed to have evolved in the United States.

There are several species of naegleria, but only the N. fowleri species causes human disease. 

Like other amoebas, naegleria reproduce by cell division. When conditions are less than optimal, amoebas become inactive cysts. When conditions are favorable, the cysts turn into trophozoites -- their feeding form. These trophozoites can also temporarily grow tails that allow them to swim. In this tailed form they cannot eat, so they soon revert to the trophozoite stage.

Naegleria love warm temperatures and are able to survive in water as hot as 113 degrees Fahrenheit.

These amoebas can be found in warm places around the globe. They are found in:

Warm lakes, ponds, and rock pitsMud puddlesWarm, slow-flowing rivers, especially those with low water levelsUntreated swimming pools and spasUntreated well water or untreated municipal waterHot springs and other geothermal water sourcesThermally polluted water, such as runoff from power plantsAquariumsSoil, including indoor dust

Naegleria can't live in salt water and cannot survive in properly treated swimming pools or in treated municipal water.

Most cases of N. fowleri disease occur in Southern or Southwestern states. Over half of all infections have been in Florida and Texas. However, a recent case in Minnesota suggests either that the amoebas are more common in Northern states than previously known, or that they are spreading into these states.

The moniker "brain-eating amoeba" makes naegleria sound like tiny zombies wandering about looking for a way into your skull. But brains are accidental food for them, says Jonathan Yoder, MPH, who tracks the deadly amoeba for the CDC.

"It is normally eating bacteria in its natural environment, but for some reason it does use the brain as a food source when it gets into humans," Yoder tells WebMD.

If you were to drink a glass of water infested with naegleria, you would not get a brain infection. Infection occurs only after water (or perhaps dust) containing the amoeba gets into the nose.

This appears to happen most often when people are diving, water skiing, or performing water sports in which water is forced into the nose. However, infections have occurred in people who dunked their heads in hot springs or who used untreated tap water to cleanse their nostrils.

Studies suggest that N. fowleri amoebas are attracted to the chemicals that nerve cells use to communicate with one another. Once in the nose, the amoebas travel through the olfactory nerve into the frontal lobe of the brain.

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Posted in: Amoeba,BrainEating

PHEN375: The Actual Weight Reduction Solution

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By EricHanson | July 18, 2011

If у?? аrе looking t? shed weight, а?? lose t?е weight fаѕt, t?е? у?? са? b?у phen375. It іѕ quite a fаѕсі?аtі?? product, аѕ іtѕ regular ?ѕе w???? ensure t?аt t?е pounds decrease а?? а?? іt’s completed very easily, ѕі?се іt doesn’t ?а?е а?у unwanted effects. It іѕ scary t? consider t?аt ?t?еr diet pills ?а? сеrtаі? unwanted effects including constipation, higher heartrate, lack ?f sleep, blood pressure а?? аt times addiction.

T?еѕе kinds ?f side effects аrе never found і? regards t? t?е phen375 product, а?? а?? t?аt у?? wі?? ?а?е t? concern yourself wіt? іѕ ??w much ?f bodyweight у?? wish t? remove.

Many ?f t?е testimonies t?аt wе ?а?е read а?? і? addition fr?m t?е critiques ?f t?е diet pill t?аt urge anyone t? b?у Phen375 іѕ t?е competent amount ?f weight loss, wіt? m?ѕt ?f іtѕ buyers calculating between 2 а?? five lbs decrease і? weight і? a span ?f one week. T?іѕ really іѕ rаt?еr remarkable, а?? depending ?? ??w much у?? truly weigh before deciding t? ?ѕе t?іѕ weight loss pill, у?? са? shortly enter у??r expected weight range і? a few weeks.

It’s а?ѕ? wise t? B?у Phen375 cheap bеса?ѕе t?еу take a two-pronged strategy і? helping у?? wіt? у??r weight reduction, w?іс? mау t?е? с?аrіfу w?у іt іѕ quite rapid wіt? regard t? t?е speed аt w?іс? t?е weight decreases. T?е key mechanism іѕ referred t? аѕ fаt burning, w?іс? means t?е decrease і? t?е total amount ?f fаt і? one’s body bу improving t?е rate ?f metabolism і? t?е body. T?е е?? result ?f improved metabolism іѕ t?аt t?е weight і? у??r body іѕ changed і?t? energy. Wіt? time t?іѕ w???? result і? a reduction ?f t?е body weight.

W?е? у?? ?есі?е t? b?у phen375, bе cautious ??t t? bе deceived bу t?е various scams w?іс? аrе t?еrе, іt іѕ іmр?rtа?t t?аt t?е seller fr?m w??m у?? аrе purchasing t?е product іѕ а? individual w?? іѕ ???еѕt. T?е best option w???? bе t? р?rс?аѕе fr?m t?е manufacturer, ?іkе fr?m t?е official website ?f t?е producer і? q?еѕtі??. Here, у?? аrе sure t?аt t?е acquisition ?f t?е tablet wі?? bе wіt? a 6 week cash back guarantee, plus a meal р?а? t?аt wі?? guide у?? through 1 month ѕ? у?? mаkе t?е best fr?m t?е best diet pills у?? са? find аt t?е moment.

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Posted in: Actual,PHEN375,Reduction,Solution,Weight

Coroners 'turning a blind eye' to assited suicide

At least one in 10 suicides in England is by someone with a chronic or terminal illness, found researchers who tried to obtain information on the subject from local health authorities.

Coroners told them that people were increasingly killing themselves at a younger age, rather than waiting until they were in severe pain in their 80s or 90s.

And two of 15 coroners interviewed also indicated they deliberately avoided probing into possible cases of assisted suicide - which remains illegal in Britain - "often for fear of causing problems for the friends and family left behind".

One retired coroner admitted: "There have been many cases where I had suspicions, but I would not see it as my specific job to delve into it. If I had no option then I would, but you might say I didn’t want to know."

Another coroner said: "If it was obvious, I would have to inform the police, as assisting suicide is a criminal offence."

But he added: "Normally it is the case that someone has informed their partner they want to end their pain or suffering.

"When a relative tells me this I try not to push them as to whether they were therefore aware the person was going to kill themselves."

The authors of the report, The Truth About Suicide, said such comments amounted to "evidence that coroners sometimes turn a blind eye to suspicions over assisted suicides".

Last year (2009-10) 19 cases of assisted suicide were reported to Keir Starmer, the Director of Public Prosecutions. No action has yet been taken on any of them.

The Demos report concluded that, in light of the interviewed coroners' admissions, "the actual number of assisted suicide cases is likely to be higher than official records suggest".

The core focus of the report was suicide among people with chronic or terminal illness, and not assisted suicide itself.

The authors said there was a dearth of information on the subject - only 29 or 147 NHS primary care trusts could provide data.

Louise Bazalgette, the lead author, explained that coroners were not required to include details of the deceased's medical history as part of the inquest.

But she said their research indicated at least 400 people with chronic or terminal illness committed suicide every year in England.

She commented: "The lack of attention paid to people with terminal or chronic illness committing suicide is a gross dereliction of duty on the part of the government and health services."

Demos is to present the report to the Commission on Assisted Dying, chaired by Lord Falconer, the former Lord Chancellor, later this year. It is examining areas where the law might be changed.

Advocates of legalising assisted suicide, such as Sir Terry Pratchett, the author, say people with terminal conditions are being forced to travel abroad to die at the Dignitas clinic in Switzerland because of the law here.

Defenders of the existing system fear legalisation will open the door to abuse, and that elderly people will be pressured to end their lives so as not to be a burden on relatives.

Guidance on the existing law, drawn up by Mr Starmer and published 18 months ago, say charges should only be likely when financial gain is shown to be the main motivation.

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Posted in: assited,blind,Coroners,suicide,turning

Cracking Gym Jokes

Sorry, I could not read the content fromt this page.Sorry, I could not read the content fromt this page.

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Posted in: Cracking,Jokes

No ‘Weekend Effect’ at Specialized Stroke Centers

At Specialized Stroke Centers, Patients Admitted on Weekends Fare as Well as Patients Hospitalized on Weekdays, Study Finds

Aug. 25, 2011 -- If you think hospitals aren’t as good at treating strokes on weekends as they are on weekdays, reconsider. A new study shows that the so-called “weekend effect” doesn’t apply everywhere.

And besides, the stakes are way too high to ever delay seeking care.

No matter what day of the week it is, “if you think you or someone you love is having a stroke, call 911,” says Roger Bonomo, MD, director of stroke care at New York's Lenox Hill Hospital. “Don’t wait until Monday.”

Warning signs of stroke include:

Sudden weakness or numbness in the face, arm, or leg on one side of the bodySudden confusion, trouble speaking, or understandingSudden trouble seeing in one or both eyesSudden trouble walking, dizziness, loss of balance or coordinationSudden, severe headache with no known cause

The weekend effect suggests that people who are admitted to a hospital on weekends with a stroke don’t fare as well as those hospitalized on weekdays. The reasons for this effect vary, but may be because of reduced hospital staff on weekends.

Stroke patients who were admitted to hospitals in New Jersey over the weekend were 5% more likely to die within 90 days than people who were hospitalized during the normal work week unless they were treated at comprehensive stroke centers. The study appears in Stroke.

There are likely several reasons that there was no weekend effect seen at comprehensive stroke centers, James S. McKinney III, MD, tells WebMD in an email. He's an assistant professor of neurology at University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School in New Brunswick, N.J.

“Services [at comprehensive stroke centers], such as physical therapy, [imaging] availability, or acute stroke teams, work around the clock to ensure that all patients are treated the same regardless of the time or day of admission,” McKinney says.

“This is another important study adding to the evidence that treatment at stroke centers can improve outcomes for stroke,” Ralph Sacco, MD, tells WebMD. He's chair of neurology at the University of Miami Miller School of Medicine and immediate past president of the American Heart Association. These centers and the doctors who work at them have the “soup-to-nuts ability to handle all kinds of complicated strokes," Sacco says.

Most Americans live within one hour of a stroke center. So access to specialized stroke centers is improving, he says.

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Posted in: Centers,Effect,Specialized,Stroke,Weekend

Under-Nutrition During Childhood Leads To Greater Risk Of Heart Disease In Later Life

Editor's Choice
Academic Journal
Main Category: Heart Disease
Also Included In: Pediatrics / Children's Health;  Cardiovascular / Cardiology;  Nutrition / Diet
Article Date: 25 Aug 2011 - 8:00 PDT window.fbAsyncInit = function() { FB.init({ appId: 'aa16a4bf93f23f07eb33109d5f1134d3', status: true, cookie: true, xfbml: true, channelUrl: 'http://www.medicalnewstoday.com/scripts/facebooklike.html'}); }; (function() { var e = document.createElement('script'); e.async = true; e.src = document.location.protocol + '//connect.facebook.net/en_US/all.js'; document.getElementById('fb-root').appendChild(e); }()); email to a friend   printer friendly   opinions  

A study published online today in the European Heart Journal research showed the first concrete evidence that acute under-nutrition during the time that children grow up can have a significant impact on their future health.

Researchers conducted a study on women who were children, teenagers or young adults during the Dutch famine in 1944-45 and discovered that an increased risk of coronary heart disease in later life is linked to under-nutrition, particularly in the adolescent years.

The authors of the accompanying editorial, state that the discovery stresses the importance for policy makers and health professional to take these findings into account for designing and implementing disease screening and prevention programs. ?

Researchers from the University Medical Center in Utrecht and the University of Amsterdam conducted a study of 7,845 women who were aged between 0-21 and were living in The Netherlands at a time when a combination of circumstances at the end of the Second World War resulted in severe food shortages in the west of The Netherlands. During the period from October 1944 official daily rations for the general adult population dropped from 1400 calories to between 400-800 calories at the height of the famine from December 1944 to April 1945. Six months later, the liberation of the Netherlands ended the famine abruptly. ?

Female participants for the study were recruited from 1993 to 1997 through a breast cancer-screening program that was followed up until the end of 2007. The researchers divided the women into three groups. The first group consisted of women who were unexposed, i.e. women who reported being "hardly" exposed to hunger and weight loss during the famine; the second group containing those severely exposed, i.e. women who reported being "very much" exposed to hunger and weight loss with the third group containing those with moderate exposure, i.e. the remaining women whose famine experience was somewhere between these two experiences. ?

? They discovered that the risk of coronary heart disease in comparison with unexposed women, was marginally higher overall for women with moderate exposure to the famine, and significantly higher among those who had been severely exposed.

Women with severe exposure, who were aged between 10-17 at the start of the famine had a statistically significant 38% increased risk of coronary heart disease in later life compared to those who had been moderately exposed. Women who were unexposed had no increased risk. The researchers adjusted factors that could misconstrue the results, such as age at start of the famine, smoking, and education (as a measure of socio-economic status) and discovered a 27% increased risk of coronary heart disease for the severely exposed women compared to those unexposed.

Additional examinations revealed that the risk of stroke seemed to be lower for women of all ages exposed to famine, compared to those who were not exposed. Women who were exposed to famine at the ages between 18 to 21 years (ages that are not sensitive growth periods) seemed to have a lower risk of stroke compared to those who were unexposed, although this lower risk was not statistically significant.

? The authors imply the relevance of the study's results for today by commenting that:

"The Dutch famine of 1944-45 is a 'natural experiment' in history, which gave us the unique possibility to study the long-term effects of acute under-nutrition during childhood, adolescence, and young adulthood in otherwise well-nourished girls and women. Our findings support the notion that disturbed postnatal development, particularly in adolescence, can have important implications for adult health. The contemporary relevance of our findings is that famine and under-nutrition are still a major problem worldwide; the first millennium developmental goal is to eradicate extreme hunger. Since the incidence of CVD [cardiovascular disease] is the number one cause of death globally, and rising in many parts of the world, further research into the impact of under-nutrition during sensitive periods of growth and maturation is warranted."? ?

Annet van Abeelen (a PhD epidemiology student at the Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and at the department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam (The Netherlands) who is the first author of the study), added that more research was needed to confirm the findings and to explore the possible mechanisms underlying the effects of famine on the risk of future heart disease.? ?

She commented:

"However, our study pinpoints the crucial role childhood plays in adult health. More knowledge in this field may lead to unique opportunities for prevention in the future.

According to the developmental origins of chronic disease hypothesis, as first proposed by Professor David Barker, nutritional influences early in life may change the structure and function of the body. While these changes may be beneficial for short-term survival, they may lead to chronic diseases in later years. Our study indicates that growth that has been hampered by under-nutrition in later childhood, followed by a subsequent recovery, may have metabolic consequences that contribute to an increased risk of diseases later in adulthood."? ?

The authors have several possible explanations for the effects of famine on coronary heart disease, such as unhealthy lifestyles, changes in metabolism, or traumatic stress, but commented that each of these required further research. Ms van Abeelen added that more research was also required for the findings on stroke considering that these results were based on just 235 stroke cases. ? ?

Professor Kausik Ray and colleagues at St George's University of London (London, UK), writes in an accompanying editorial:

"These results add further weight to the suggestion that adolescence is a particularly sensitive period open to epigenetic modifications and that dietary mismatch in post-famine nutritional availability contributes to coronary disease risk."

The authors highlight that according to the United Nations Food and Agriculture Organization 925 million people worldwide are undernourished and that a recent report by the Association of Teachers and Lecturers in the UK revealed, that three-quarters of their students arrived at school hungry with these numbers increasing since the start of the global recession. ?

Prof Ray and colleagues relate to studies of people who starved during the Chinese famine (1959-61) and the siege of Leningrad (1941-44) in their comment:

"Taken together there appear to be consistent data showing that nutritional status in childhood may impact significantly on chronic diseases processes in later life. The findings of these recent studies could have significant practical impact on immigrant populations who try to adapt to the relatively more affluent and nutritionally rich environments, particularly those escaping from man-made and natural catastrophes. For instance, first-generation Asians in the UK have a higher incidence of cardiovascular disease than Caucasian counterparts. As cardiovascular disease carries the largest economic and population burden in developed countries and is fast approaching similar importance in developing countries, further work is now needed to better understand the mechanisms behind these associations and devise public health strategies which could have a significant impact on disease burden in years to come."?

Written by Petra Rattue
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today

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Posted in: Childhood,disease,During,Greater,Heart,Later,Leads,UnderNutrition

Vitamin D Confirmed As A Protective Agent Against The Advance Of Colon Cancer

Main Category: Colorectal Cancer
Also Included In: Nutrition / Diet
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The indication that vitamin D and its derivatives have a protective effect against various types of cancer is not new. In the field of colon cancer, numerous experimental and epidemiological studies show that vitamin D3 (or cholecalciferol) and some of its derivatives inhibit the growth of cancerous cells. Researchers at the Vall d'Hebron Institute of Oncology (VHIO), in collaboration with the Alberto Sols Institute of Biomedical Research (CSIC-UAB), have confirmed the pivotal role of vitamin D, specifically its receptor (VDR), in slowing down the action of a key protein in the carcinogenic transformation process of colon cancer cells. These results are being published in the journal PLoS One.

This protein, known as beta-catenin, which is normally found in intestinal epithelial cells where it facilitates their cohesion, builds up in large quantities in other areas of the cells when the tumour transformation begins. As a result of these changes, the protein is retained in the cell nucleus, where it facilitate the carcinogenic process, and this is the point at which vitamin D intervenes, or rather, the vitamin D receptor (VDR). "Our study has confirmed the pivotal role of the VDR in controlling the anomalous signal that sparks off the growth and uncontrolled proliferation of colon cells which, in the final instance, ends up causing a tumour to emerge", says Hector Palmer, the coordinator of this study and head of the VHIO's Stem Cells and Cancer laboratory. He continues, "The stimulation of this receptor suppresses the action of the beta-catenin protein, intercepting the series of events that change the intestinal cell into a malignant tumour cell".

The study was conducted on mice and human colon cancer cells. The mice were used as a model to replicate the initial phases of colon cancer. "These findings show that mice of this kind, which also lack the VDR and hence do not respond to vitamin D, present larger and more aggressive tumours than mice with the VDR", explains Dr. Palmer, and concludes: "The number of tumours is not influenced by the absence of VDR, which would indicate that this factor does not protect against the appearance of the tumour but does intervene in its growth phase, reducing its aggressiveness".

The researchers then analysed the effect of the VDR on human colon cancer cell cultures and observed that the concentration of the altered protein, beta-catenin, increased in cells without the VDR. These findings were repeated in the three types of colon cancer cells studied, and confirmed the results observed in the mice.

In two-thirds of advanced colon cancer tumours there was a lack of VDR in the cancer cells, and this circumstance leads us to believe that this loss may contribute to speeding up the growth of the tumour. The findings of this study confirm this supposition.

Vitamin D: essential in the initial phases of colon cancer

In light of these findings, chronic vitamin D deficiency represents a risk factor in the development of more aggressive colon tumours. Patients in the initial stages of colon cancer, the time when the VDR still has a substantial presence in the cells, could benefit from being treated with vitamin D3. However, this would not be useful in the advanced stages of the disease when the presence of the VDR is very much reduced.

The study data support the development of anti-tumour medicines based on the structure of vitamin D, although their use in patients will require further research in the next few years.

The body not only obtains vitamin D from food, especially milk and fish oils, but also manufactures it from exposure to sunlight. Prolonged exposure is not necessary; just 10 minutes in the sun every day when it is not at its peak is sufficient to stimulate its production. During the summer, when we are more likely to sunbathe, it is important to use the appropriate protective measures against sunburn to avoid future sun damage. Use high-factor solar protection products and do not expose the skin to the sun in the middle of the day to protect against skin cancers.

Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.

posted by Peggy on 18 Aug 2011 at 5:40 am

So what is the recommended daily amount of Vitamin D for cancer prevention? In a woman? Older woman? Man?

| post followup | alert a moderator |

posted by William B. Grant on 18 Aug 2011 at 2:04 pm

From observational studies, it appears that good protection against breast, colon, rectal and other cancers is achieved for serum 25-hydroxyvitamin D levels above 40 ng/mL (100 nmol/L). To achieve this level takes anywhere from 1000 to 5000 IU/d vitamin D3 or more, depending on various personal factors.

| post followup | alert a moderator |

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Posted in: Advance,Against,Agent,Cancer,Colon,Confirmed,Protective,Vitamin

Mott’s 100% Fruit Punch Juice 9 pk

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What Is The Best Exercise For Weight Loss?

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By EricHanson | August 17, 2011

It іѕ a common misconception t?аt aerobic fitness exercise tones а?? firms muscles. Actually іt accomplishes very ?іtt?е toning а?? firming. Resistance exercise (weight training) іѕ w?еrе real toning а?? firming ?f muscles occurs.

Doing both aerobics а?? weight training іѕ t?е optimal method t? lose more fаt а?? gain more muscle. If у???re attempting t? lose weight, tests а?ѕ? ѕ??w t?аt weight reduction increases bу 56 % wіt? aerobic а?? strength exercises combined.

Muscle mау weigh more, nevertheless w?е? у?? boost у??r muscle composition, у??r body іѕ аb?е t? burn up more fаt, even w?е? у?? аrе resting, bеса?ѕе у??r metabolism іѕ higher. A pound ?f muscle ?ѕе 350 t? 500 kcalories per week t? survive, w?і?е a pound ?f fаt ???у needs аb??t 14 kcalories weekly. Nеw studies demonstrate t?аt building muscle helps у??r system fight illness better, t??.

Strength training benefits е?еrу one, ?? real matter w?аt age ?r sex, а?? іѕ becoming named а? іmр?rtа?t element ?f fitness. Research іѕ indicating t?аt t?е muscle loss within seniors doesn’t originate fr?m age, b?t lack ?f activity. A young one w?? doesn’t ?еt enough exercise са? lose muscle mass а?? strength. Weight training, such аѕ f?r instance strength training ?r performing weight-resistance exercises, аѕ low аѕ twice a week mі??t ?е?р maintain ?r increase muscle tissue.

Strength training involving several sets ?f multiple repetitions using moderate weights won’t lead t? ???е muscles. Alternatively іt builds bone mass а?? increases t?е metabolism, along wіt? toning а?? firming t?е muscles, giving a leaner look.

It іѕ very іmр?rtа?t t? accomplish both aerobics а?? strength exercises. T?е cardio exercises ?е?р у??r heart а?? lungs ?еt stronger а?? ?е?р у??r body utilize oxygen more proficiently, w?іс? supports strength training а?? over а?? fitness. T?е strength exercise helps develop muscle, reduce surplus fаt а?? continue maintaining bone mass.

Aerobic fitness exercise іѕ a kind ?f exercise t?аt elevates t?е center rate а?? breathing f?r a continuous sustained period. T?іѕ overloads one’s heart а?? lungs а?? causes t?еm t? work harder t?а? аt rest.

T?еrе аrе lots ?f options t? с???ѕе fr?m today. Bicycling, aerobic dance, swimming, walking, а?? stepping аrе examples ?f aerobic exercise. W?іс? ones t? с??ѕе depends upon у??r shape, у??r history, у??r interests а?? у??r goals. Many experts believe іt іѕ easier t? alternate between 2 ?r maybe more types, t? obtain a better workout.

Y?? са? find two main types ?f aerobics- high impact а?? low impact. It іѕ better t? alternate between high impact aerobics (w?іс? аrе harder ?? t?е human body а?? mі??t cause more ?аmа?е) а?? low impact aerobics, such аѕ f?r example walking а?? swimming. T?іѕ іѕ called cross-training, а?? helps decrease t?е chance ?r injury а?? over-?ѕе ?f сеrtаі? muscles.

Y?? wі?? need t? perform cardio vascular exercises аt ?еаѕt 20 minutes a day f?r аt t?е ?еаѕt three ?r four days per week. If у?? аrе attempting t? lose surplus fаt, ?r у??r shape іѕ ?rеаt, t?е? у?? mі??t want t? work longer аt іt. Try exercising up t? 40 t? 60 minutes 5 t? 6 days per week.

Remember t?еrе іѕ ?? real need сеrtаі??у t? overload. Moderate intensity іѕ nearly always better, а?? іѕ more enjoyable. Low t? moderate intensity са? bе а? particularly ???? notion w?е? getting ѕtаrtе? аftеr a layoff ?r recovery fr?m disease ?r injury, ?r іf у???re significantly overweight.

Warm-up а?? с???-down іѕ very іmр?rtа?t t? reduce disquiet а?? t?е possibility ?f injury. Warm up bу starting ѕ??w а?? gradually build-up t? у??r top speed. T?е? ѕ??w down again bу t?е е?? ?f one’s work-out.

T?е complete і?еа behind t?е best exercise f?r weight loss іѕ always t? ?еt fully up а?? асq?іrе moving! Find something у?? ?іkе doing t?аt keeps у??r heartbeat elevated f?r a continuous time period а?? асq?іrе moving t? a healthier life.

F?r those w?? аrе searching Internet f?r more info аb??t t?е niche ?f weight loss, t?е? mаkе sure t? check out t?е web page t?аt wаѕ mentioned rі??t і? t?іѕ passage.

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Posted in: Exercise,Weight

Study: HPV Tests Better at Predicting Cervical Cancer Than Pap Tests

No Significant Gain From Combining the Tests, Study ShowsBy Brenda Goodman
WebMD Health News

Aug. 22, 2011 -- DNA tests that detect the most virulent strains of human papillomavirus, or HPV, may find more advanced precancerous cells that can lead to cervical cancer than traditional Pap smears, a new study shows.

The study, which is published in The Lancet Oncology, suggests that testing for HPV strains 16 and 18, which cause about 70% of all cervical cancer, could replace Pap tests as the primary screening tool for the disease.

“We’re not there yet, but this trial gives us more data that shows that it is reasonable to consider HPV as a standalone test,” says Therese Bevers, MD, medical director of the Cancer Prevention Center at the University of Texas M.D. Anderson Cancer Center in Houston. 

The study of more than 40,000 healthy women over age 25 found that HPV testing correctly detected nearly 40% more advanced precancers than Pap smears did.

“There are still points to be worked out, but clearly this study is providing more data to say that this may be a strategy that’s reasonable to consider,” says Bevers, who was not involved in the research.

Importantly, the study also found that combining HPV and Pap testing, as many doctors do, only found about 5% more advanced precancers and cancers, but it increased the number of women who falsely tested positive by more than one-third.

“You get a 5% gain for a 35% over-referral,” says study researcher Mark H. Stoler, MD, professor of pathology and clinical gynecology at the University of Virginia Health System in Charlottesville, Va.

Those false-positive tests lead to more frequent or invasive testing to rule out cancer, more anxiety for patients, and more expense for individuals and insurance companies.

“The study suggests that if you’re really concerned about efficiency with very little penalty, then HPV testing should be the first test,” Stoler tells WebMD.

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Posted in: Better,Cancer,Cervical,Predicting,Study,Tests

Research Identifies How Vitamin D Combats MS

Main Category: Multiple Sclerosis
Also Included In: Nutrition / Diet
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While for years scientists have noted an association between levels of vitamin D in a person's body and the person's ability to resist or minimize the effects of multiple sclerosis (MS), the mechanism involved has not been established. However new research by Sylvia Christakos, Ph.D., of UMDNJ-New Jersey Medical School (principal investigator) Sneha Joshi (first author, a UMDNJ Ph.D. student), and colleagues (including co-investigator Lawrence Steinman, MD, of Stanford University) appears to have uncovered that process. The study, published in the journal Molecular and Cellular Biology, finds that vitamin D directly terminates the production of a disease-causing protein.

During MS ("EAE" in mice), a damaging protein called interleukin-17 (IL-17) is produced by immune cells in the brain. The investigators, a collaborative team of scientists from the University of Medicine and Dentistry of New Jersey and Stanford University, find that after vitamin D binds to its receptor, the receptor parks itself on the gene that encodes IL-17. By doing so, the receptor occupies a site normally reserved for a protein called NFAT, which is required to turn the gene on. The gene stays off and IL-17 levels plummet.

At the same time, the vitamin D receptor turns on another gene, whose product generates suppressive T cells that combat the destructive action of their IL-17-producing counterparts.

According to the researchers, the mechanism they identify suggests what might be a new path toward pharmaceutical treatment of MS, as well as therapies for other autoimmune diseases that might include rheumatoid arthritis, type 1 diabetes, eczema and psoriasis.

Source: University of Medicine and Dentistry of New Jersey (UMDNJ)

Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.

posted by Annette on 20 Aug 2011 at 7:15 am

The title was fascinating and hopeful. As I read it I realized that when it came time to vote I just sort of ...hovered over the three! -It says I gave it a 3.5, but it's supposed to only be a three.- Rather than assuming I had been taken over by some silly entity that weighs in on articles only, I thought: Where does this disappointment come from? I realized then that this easy way of taking vitamin D was not explained to us. Is it D3? What dosage were the test subjects taking? Lastly, I suspect that the researchers, the grant supporters, etc. will probably come up with some elaborate way to package the application method, the formulation of a VITAMIN D compound that will magically make that particular vitamin disappear off the shelves so one can only get the doctor/FDA approved, ridiculously expensive version. I hate being this cynical, so tell us the dosage and type of vitamin D used already!

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posted by Renee on 22 Aug 2011 at 10:49 am

This information sounds promising. Please tell me how much Vitamin D is recommended.

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Posted in: Combats,Identifies,Research,Vitamin

Sugar May Speed Up Drug Development

Editor's Choice
Academic Journal
Main Category: Biology / Biochemistry
Also Included In: Nutrition / Diet
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The surface of cells and several biologically active molecules are dotted with sugar structures that instead of storing energy are involved in communication, immunity and inflammation. Similarly, sugars attached to drugs can increase, change or neutralize their effects. Jon Thorson, a professor of pharmaceutical sciences at the University of Wisconsin-Madison School of Pharmacy explained. On Aug. 21, the investigation was published online in Nature Chemical Biology.

According to Thorson, a professional in the attachment and function of these sugars, understanding and controlling them has huge potential for improving medications. As several new sugars are hard to create and manipulate, investigators have become frustrated. Thorson says, "The chemistry of these sugars is difficult, so we have been working on methods to make it more user friendly."

Thorson, graduate student Richard Gantt and postdoctoral fellow Pauline Peltier-Pain, have described an easy method to separate the sugars from a carrier molecule, then attach them to a drug or other chemical. Only among those molecules that have accepted the sugar, the method triggers a change of color. This color change should help a screening system to easily select out transformed moleules for further testing. Therson states, "one can put 1,000 drug varieties on a plate and tell by color how many of them have received the added sugar."

Attached sugars play a crucial role in pharmacy, not only can they change the solubility of a compound, he says, but "there are transporters in the body that specifically recognize certain sugars, and pharmaceutical companies have taken advantage of this to direct molecules toward specific tissue or cell types. If we can build a toolbox that allows us to make these molecules on demand, we can ask, 'What will sugar A do when it's attached to drug B?'"

Even though the new investigation concentrated more on an improved method instead of the alteration of drugs, it does explain the production of a few really interesting sugar-appended drugs: anti-virals, antibiotics, anti-cancer and anti-inflammatory medications. Currently under way are follow-up investigations to discover the potential of these analogs.

11 variants of vancomycin, a powerful antibiotic, each distinguished by the nature and number of attached sugars, were included in the new molecules.

The base of the new technique is its starting point, a molecule that changes dynamics of the sugar-attachment reaction. Thorson explains,

"This is one of the first systematic studies of the equilibrium of the reaction, and it shows we can drive it forward or in reverse, depending on the molecule that we start with."

The new method is able to separate the sugar from its carrier and reattach it to the biological target molecule in a single test tube. He says,

"Sugars are involved in a vast range of biology, but there are still many aspects that are not well understood about the impact of attaching and removing sugars, partly because of the difficulty of analyzing and accessing these species."

Making variations of potential and existing medications is standard practice for drug-makers. A recently published investigation by Peltier-Pain and Thorson, showed that attaching a certain sugar to the anti-coagulant Warfarin kills its anti-clotting ability. However, the transformed molecule "suddenly becomes quite cytotoxic - it kills cells," Thorson says, "We don't know the mechanism, but there is some interest in using it to fight cancer because it seems to act specifically on certain cells."

Sugars are also attached to proteins, cell surfaces and many other locations in biology, Thorson says,

"By simplifying the attachment, we are improving the pharmacologist's toolbox. This study provides access to new reagents and offers a very convenient screening for new catalysts and/or new drugs, and for other things we haven't yet thought of. We believe this is going to open up a lot of doors."

Written by Grace Rattue

Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today

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Posted in: Development,Speed,Sugar

Achieving Healthy Weight Gain

While most Americans struggle to lose weight, there are some who are underweight and unable to gain enough weight to stay in the healthy range.  While certain individuals may inherently have a high metabolism, others may have an illness or chronic condition that prevents them from maintaining a healthy weight.  Cancer treatments, for example, may cause nausea and food aversions.  People with gastrointestinal or liver problems may be unable to absorb nutrients adequately even if they are consuming what would normally be a sufficient amount for a healthy individual.  Mental well-being is an important aspect of weight maintenance as well.  People who suffer from depression, stress, or anxiety may have loss of appetite and subsequent weight loss.

Being underweight is associated with medical problems including osteoporosis, low muscle mass, weak immune systems, poor wound healing, and infertility.  Children who are underweight may have stunted growth and poor brain development.  In adults, underweight is defined as having a body mass index (BMI) less than 18.5.  In children, underweight is defined as having a BMI less than the 5th percentile for age and gender because the healthy range of BMI varies with gender and changes over time as children get older.

If you or someone you know is trying to gain weight, it does not mean that junk food or fast food meals are acceptable.  The goal is to increase caloric intake, but these calories should still be accompanied by nutrition.  The following suggestions are some simple ways to add tasty, healthy calories to the diet.

Mini-meals.  Sometimes the thought of having to eat more at any one meal can appear to be a daunting task, especially if nausea or reflux symptoms are a problem.  Rather than focusing on bigger meals at breakfast, lunch, and dinner, try having regular meals at those times but add three snacks throughout the course of the day. 

Beverages.  Drinking calories is just as good as eating calories.  Be wary of soft drinks and juice, though, since these beverages often just add sugar to the diet.  Juice should be limited to no more than one glass per day if at all.  Substituting a glass of water with a glass of milk will provide more calories, protein, and calcium.  Make high protein smoothies by adding yogurt or soft tofu to milk and fresh or frozen fruit.  You can add other things like wheat germ or dry milk powder to increase the nutritional content even more.  You can also try drinking beverages after eating so that you do not fill up on fluid before finishing your meal or snack.

Protein.  Sufficient amounts of protein are important for building muscle mass.  Healthy snacks with nuts or dairy products like cheese and yogurt are easy ways to increase protein.  Fruits can be dipped in yogurt, and crackers or vegetables can be paired with peanut butter, hummus, or bean dip.  Beans and legumes, eggs, or lean cuts of meat, fish, and poultry are also key ingredients for adding protein at mealtime.  Hard-boiled eggs can be a quick and easy snack or an addition to a salad.

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Posted in: Achieving,Healthy,Weight

Risk for Mental Illness Varies by Gender

Women More Likely Than Men to Be Diagnosed With Depression or Anxiety

Aug. 23, 2011 -- Women are more likely to be diagnosed with depression and anxiety, while men are at greater risk for substance abuse and antisocial disorders, according to a new study examining gender differences in rates of mental illnesses.

The gender differences may be related to how the sexes deal with their emotions. Women are more likely to internalize their emotions and withdraw, leading to depression and anxiety. Men, however, are more likely to externalize their emotions and act out.

“It is not that major depression itself is significantly higher in women than in men; rather, our study suggests that internalizing [behavior] is higher in women than in men, and this difference is manifested in gender differences in a variety of mental disorder prevalence rates,” says study author Nicholas R. Eaton, MA, a psychologist at the University of Minnesota in Minneapolis.

The new findings, which appear in the Journal of Abnormal Psychology, may have important implications for the prevention and treatment of mental illness in women and men.

For example, coping skills and cognitive behavior therapy aimed at reducing over-thinking may help prevent full-blown depression or anxiety among at-risk women.

Eaton and colleagues analyzed data on more than 43,000 people who took part in the National Epidemiologic Survey on Alcohol and Related Conditions. Participants were interviewed about their lifetime history of mental illness, including information on any diagnosis made in the previous year. Women were more likely to be diagnosed with depression and anxiety, while men were more likely to be diagnosed with substance abuse and antisocial disorders.

Specifically, 22% of women had been diagnosed with depression during their lifetime, compared with 13.1% of men.  By contrast, 17.4% of men had a lifetime history of alcohol dependence, compared with 8% of women in the study.

“Efforts focusing solely on prevention, diagnosis, and treatment of specific mental disorders misses an important part of the picture,” Eaton says in an email. The new findings provide new ways of predicting future mental health, he says.

The new findings make sense to Philip D. Harvey, PhD, a professor of psychiatry and behavioral sciences at the University of Miami Miller School of Medicine in Florida.

“We do see more anxiety and depression in women and more psychosis and antisocial behavior in men,” he says.

This is the rule, but there are exceptions, he says. “Yes, there are gender differences, but there is no such thing as gender exclusivity,” he says.

Men can have depression or anxiety disorders and should not be discouraged from seeking treatment, he says.

Understanding gender differences is a big issue in all areas of medicine today, including psychiatry, he says. The National Institutes of Health will only fund grants that include women and minorities and also encourages that the findings be analyzed by gender.

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Posted in: Gender,Illness,Mental,Varies

Zelboraf Approved for Late-Stage Melanoma

Drug Cuts Death Risk for Melanoma Patients With BRAF Mutation

Aug. 17, 2011 -- The FDA today approved Zelboraf, a drug that can extend survival for the 50% of melanoma patients whose tumors carry the BRAF V600E mutation.

Zelboraf is approved for inoperable or late-stage melanoma that tests positive for the BRAF mutation. In concert with the drug approval, the FDA also approved a new test for the BRAF mutation.

Zelboraf does not cure melanoma, which this year will kill some 9,000 Americans. But Zelboraf will make a big difference in the lives of BRAF-positive melanoma patients, says Anna Pavlick, DO, co-director of the melanoma program at New York University's Cancer Institute. Pavlick was one of the investigators in Zelboraf clinical trials.

"We now have the capacity to analyze a patient's melanoma tumor for the genetic mutation BRAF and use the targeted treatment Zelboraf to attack the tumor, shrink it, and stop the progression of this deadly disease," Pavlick says in an NYU news release. "The drug comes in a simple pill form, taken twice a day, and has been well tolerated by patients."

Nevertheless, Zelboraf has some serious side effects. Some 26% of patients in clinical trials developed a nonmelanoma form of skin cancer called cutaneous squamous cell carcinoma, which can usually be removed via relatively simple surgery.

Other side effects include joint pain, rash, hair loss, fatigue, nausea, and skin sensitivity to sunlight. Patients taking Zelboraf must avoid sun exposure.

An international phase III clinical trial of Zelboraf in 675 BRAF-positive patients was stopped early when it became clear that the drug was clearly reducing deaths. All patients assigned to traditional chemotherapy were offered the new drug.

It's not yet clear how long Zelboraf can increase melanoma survival. In the phase III study, progression-free survival -- the time since treatment when disease gets worse -- was 5.3 months for patients on Zelboraf vs. 1.6 months for patients on standard chemotherapy.

"For patients with metastatic melanoma with the BRAF V600E mutation, the availability of [Zelboraf] is a major defining moment that will have an important effect on survival and quality of life," Dartmouth Medical School researcher Marc S. Ernstoff, MD, writes in a June 30 editorial in the New England Journal of Medicine.

It's been a hopeful year for melanoma patients and their families. Last March, the FDA approved Yervoy for late-stage melanoma.

Zelboraf, originally dubbed PLX4032 and given the generic name vemurafenib, was initially developed by Plexxikon Inc., a member of the Daiichi Sankyo Group of pharmaceutical companies. The drug is being co-marketed by Genentech, a division of Roche. Roche Molecular Systems makes the newly approved BRAF test.

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Posted in: Approved,LateStage,Melanoma,Zelboraf

Widespread Mislabeling In The Seafood Industry

Main Category: Nutrition / Diet
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When you buy what looks to be a nice piece of certified sustainable fish at the supermarket, you'd like to think that's exactly what you're getting. Unfortunately, things aren't always what they seem, according to researchers who have analyzed DNA isolated from store-bought, eco-labeled Chilean sea bass and report their findings in the August 23 issue of Current Biology, a Cell Press publication.

"We found that, for fish purchased in US groceries, not all those labeled as MSC-certified Chilean sea bass are actually MSC-certified Chilean sea bass," said Peter Marko of Clemson University. MSC stands for the Marine Stewardship Council, an international organization dedicated to recognizing and rewarding sustainable fishing.

In the case of Chilean sea bass, MSC certification labels should indicate that a fish was harvested from the only recognized sustainable Chilean sea bass fishery, a population living in waters surrounding the sub-Antarctic island of South Georgia and a nearby plateau called Shag Rocks, Marko explained.

In fact, some of the fish that his team purchased turned out to be other species entirely. Of those that were Chilean sea bass, some 15 percent were genetically distinct from fish collected previously from the certified fishery. One sample carried a haplotype (defined as a combination of genetic variants in cellular components known as mitochondria) that has only been found on the other side of the globe, in the southern Indian Ocean. Other haplotypes that the researchers uncovered amongst fish marked with an MSC-certified label commonly trace to South American waters, and still others had never been recorded before in previous genetic surveys.

"The simplest explanation for this result is that other species plus Chilean sea bass from other, uncertified fisheries are being added to the supply chain for MSC-certified Chilean sea bass," Marko said. Although unexpected, "the results are not exactly shocking," given widespread mislabeling in the seafood industry and potential profits to be made.

It isn't clear who is responsible for the misleading labels, given that fish pass through many hands from the time they are caught to the time they are purchased.

"There is no question that organizations like the Marine Stewardship Council are trying their best to guide consumers to sustainably harvested seafood, but it is currently difficult to guarantee the geographic origins of fish," Marko said. He added that the MSC has been working on ways to confirm fishes' origins, and the new study may serve as a model for how to go about that.

The only thing it seems that concerned consumers can really do for now is keep Chilean sea bass off their dinner menus. "At a grocery or on a plate in a restaurant, Chilean sea bass from South Georgia looks the same as Chilean sea bass from other parts of the world," Marko said.

Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.

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Posted in: Industry,Mislabeling,Seafood,Widespread